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Combined Oral Contraceptive Pill (cOCP)


Treats Acne
Regulates Periods
Treats Irregular Periods
Less Painful Periods
Prevents Pregnancy
Decreases Heavy Periods
Decreases Anemia
Decreases Monthly Blood Loss
Decreases Risk of Ovarian Cysts
Decreases Risk of Ovarian Cancer
Decreases Risk of Endometrial Cancer
Decreases Risk of Colorectal Cancer

Active Ingredients

Desogestrel (progesterone) [0.15mg] Ethinyl Estradiol (estrogen) [30 mcg]


Do NOT use if allergic to estrogen or progestin. Discuss use with a doctor before breastfeeding, may decrease milk volume.

Equivalent Generic Brands

Desogestrel / Ethinyl Estradiol

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New Questions


What is Cryselle?

Cryselle (also called Cryselle 28) is a combination birth control pill with 0.3mg norgestrel and 30 mcg Ethinyl estradiol. It is a prescription medication taken to prevent unwanted pregnancy. Cryselle is prescribed for other reasons, such as to treat moderate acne or reduce the risk of ovarian cysts in women with polycystic ovarian syndrome (PCOS).

Cryselle can prevent pregnancy by stopping the release of an egg from an ovary and by making it harder for sperm to reach the uterus or for an egg to attach to the uterus.

Cryselle Birth Control Side Effects

Most people who take Cryselle experience no side effects. If side effects occur, they are usually mild.

Some minor side effects are: headaches, nausea, breast tenderness, fatigue, and decreased sex drive. Many experience positive side effects such as: reduced acne, fewer mood swings, and lighter, easier, and less painful periods!

While very unlikely, serious side effects can occur while taking Cryselle, including blood clots. Blood clots can travel throughout the bloodstream and block blood flow to different parts of the body. This can cause potentially life-threatening issues like deep vein thrombosis, heart attack, or stroke.

The good news is that the risk of serious Cryselle side effects is extremely low. Our expert birth control doctors and Pandia Health Care Advisors can answer any questions and concerns about your birth control options.

Get Cryselle Birth Control Online + Free Delivery

Our CEO/Co-Founder, Dr. Sophia Yen, believes that all women deserve cost-effective, convenient, and confidential access to birth control. That’s why she co-founded Pandia Health—the only online birth control delivery company founded and led by women and with a doctor CEO.

Pandia Health medical doctors can prescribe Cryselle 28 or other generic equivalent like Low-Ogestrel or Ogestrel-28 for as little as $0 with insurance or $20 per pack if paying out of pocket. We also offer affordable and effective birth control alternatives if Cryselle isn’t the best option for you.


Does Cryselle cause weight gain?

There is no direct link between Cryselle and weight gain. Some women experience changes in their appetite that may lead to weight gain while taking Cryselle. Others may find that their bodies retain more fluid while taking Cryselle, even though they actually don’t gain any body fat.

Any other important information about Cryselle?

Cryselle may interact with other medications, including prescription, over-the-counter, and/or recreational drugs, or even herbal supplements and vitamins. Always let your doctor know about all the medications/supplements/vitamins you’re currently taking before starting Cryselle. Some drugs can make Cyrselle less effective, which could lead to an unintended pregnancy.

Like other oral contraceptive pills, Cryselle does not protect against sexually transmitted infections. Our CEO and Co-Founder Dr. Yen also recommends using a back-up birth control method during the first week of using Cryselle for the first time.

What precautions should I be aware of with Cryselle?

You shouldn’t smoke anyway, but especially not if you take estrogen containing birth control pills like Cryselle. Smoking increases the risk of serious side effects like blood clots, especially in women who are older than 35.

Cryselle may cause your body to hold on to fluid, so you might notice swelling in your fingers or ankles or slight increases in your blood pressure. Let your doctor know if you’re concerned about fluid retention or weight gain.

Don’t take Cryselle if you’re allergic to any of its ingredients. Signs and symptoms of an allergic reaction to Cryselle are rare and usually very mild and may include itching, hives, or dizziness. Serious allergic reactions to Cryselle can occur in very rare cases. Stop taking Cryselle and call 911 immediately if you experience swelling in the lips, mouth, or tongue, or if you have a hard time breathing.

Cryselle isn’t for everyone. Women with a history of certain medical conditions like heart disease, high blood pressure, kidney disease, liver cancer, or severe migraines should not take Cryselle. Our Pandia Health Care Advisors are standing by to help you figure out the best birth control method given your health history.

How easy is it to get Cryselle?

It’s generally easy to get Cryselle with a doctor’s prescription at any pharmacy. Talk to your doctor or speak with one of Pandia Health’s expert birth control doctors to get set up with the right birth control prescription for your health history. Our women-founded, women-led team puts our patients’ health and privacy first, so feel free to talk with us about your questions!

We accept most forms of private insurance and also offer flexible payment options for anyone without insurance.

How does Cryselle work?

Cryselle contains hormones that prevent the release of an egg from an ovary (ovulation). The prescription medication also makes changes in your cervical mucus and uterine lining (endometrium). These changes make it harder for sperm to reach the uterus and harder for a fertilized egg to implant into the uterus.

It’s easy to use Cryselle. The most important thing to remember is to take your pill at the same time every day, and no more than 24 hours apart. For 21 days in a row, you’ll take the “active” white pill. For the next 7 days in a row, you’ll take the light green “inactive” pill. This helps you stay in the habit of taking a daily pill. Your withdrawal bleed will occur during the week you’re taking your inactive pills, usually within about two to three days of inactive pills.

Can #PeriodsOptional be for real? Check out Pandia Health’s blog post here to learn more!

Does Cryselle birth control cause infertility?

It’s a myth that Cryselle birth control causes infertility. Any woman who wants to have a baby can simply stop taking Cryselle and her normal fertility should return within 3-5 days. Talk to your doctor before stopping or changing any medications.