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Premarin Vaginal Cream

5.0 - 2177 Reviews

In Stock

$456

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Premarin Vaginal Cream Benefits

  • Relief from menopausal vaginal symptoms such as dryness, burning and itching.
  • Help prevent bone loss and reduce the risk of osteoporosis in postmenopausal women.
  • Improve mood and overall quality of life for women experiencing menopause-related hormonal changes.
  • Product Details

    How to use Premarin Vaginal Cream

    How to use Premarin Vaginal Cream

    To use Premarin vaginal cream, it is important to follow the directions provided by your doctor for optimal results. Here is a step-by-step guide on how to use this medication:

    • Fill the special applicator with the prescribed amount of cream as instructed. Be sure to wash your hands before and after use.
    • Find a comfortable position, lying on your back with your knees bent and parted.
    • Gently insert the applicator high into the vagina and push the plunger to release the cream. Take care not to force it.
    • After use, clean the applicator thoroughly with warm soapy water. Pull the plunger out and wash both parts. Rinse it well and dry it before storing.

    Your provider may instruct you to use your vaginal cream differently than the product monograph. One common method is to apply a pea-sized amount to your index finger and rub it into the tissues immediately around the vaginal opening. Sometimes this will improve the hormone benefits to the vaginal introitus more directly.

    Remember to use Premarin vaginal cream regularly as directed by your doctor to maximize its benefits. Do not exceed the prescribed dosage or duration of treatment without consulting your doctor.

    If you have any concerns or questions about the usage of Premarin vaginal cream, do not hesitate to consult your healthcare provider for guidance. At Pandia Health we have expert menopause certified doctors who can determine if Premarin cream is the best menopause treatment for you. They will make sure you get a tailored menopause treatment plan to ease your menopausal symptoms. Plus we will free ship the medication straight to your mailbox!

    Vaginal Cream Side Effects

    Premarin Vaginal Cream Side Effects

    Like any medication, Premarin may cause side effects in some individuals. Common side effects may include:

    • Common side effects of Premarin may include:
    • Breast tenderness
    • Headache
    • Nausea
    • Bloating
    • Mood changes
    • Other possible side effects may include:
    • Nausea, vomiting, diarrhea, and stomach cramps
    • Mood changes and sleep problems (insomnia)
    • Cold symptoms such as stuffy nose, sinus pain, and sore throat
    • Weight gain
    • Headache and back pain
    • Breast pain
    • Thinning scalp hair
    • Vaginal itching or discharge, changes in menstrual periods, and breakthrough bleeding

    Serious side effects are rare but can include an increased risk of blood clots, stroke, heart attack, and certain types of cancer. Contact your doctor immediately if you experience:

    • Jaw or shoulder pain, chest pain or pressure, nausea, sweating
    • Slurred speech, sudden numbness or weakness (especially on one side of the body), sudden severe headache, problems with vision or balance
    • Stabbing chest pain, sudden vision loss, feeling short of breath, coughing up blood, pain or warmth in one or both legs
    • Swelling or tenderness in your stomach
    • Yellowing of the skin or eyes (jaundice)
    • Unusual behavior, memory problems, confusion
    • Pelvic pain, unusual vaginal bleeding
    • A lump in your breast

    Vaginal Cream Contraindications

    Premarin Vaginal Cream Contraindications

    You should not use Premarin if you have any of the following conditions on your health history:

    • Allergic to Premarin or any ingredients in the medication
    • Have history of blood clots: Women with a history of blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism) should avoid using Premarin. Premarin can increase the risk of blood clot formation, which can be life-threatening.
    • Have a history of heart attack, blood clot or stroke: Women with a history of heart attack or stroke should generally avoid using Premarin vaginal cream. The medication can increase the risk of cardiovascular events in individuals with a history of these conditions.
    • Liver disease: Severe liver disease or liver tumors are contraindications for the use of Premarin cream. The tablets are metabolized in the liver, and liver dysfunction can affect its clearance from the body and increase the risk of adverse effects.
    • Uncontrolled high blood pressure: Women with uncontrolled high blood pressure should be cautious when using Premarin. This medication can increase blood pressure, and individuals with pre-existing hypertension may experience further elevation of blood pressure.
    • Breast cancer or other hormone-sensitive cancers: Women with a history of breast cancer or other hormone-sensitive cancers should generally avoid using Premarin cream. It can potentially stimulate the growth of hormone-sensitive tumors.

    These contraindications are general guidelines, and individual patient factors and medical history should be considered when determining the appropriateness of using 

    Premarin as part of menopausal hormone therapy. If a doctor prescribed Premarin vaginal cream as part of your menopause treatment, your individual factors and health history should have been evaluated making sure that the medication will not put your health at risk. 



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    What is Premarin Vaginal Cream?

    Premarin Vaginal Cream is a prescription medication that contains estradiol, a form of plant-based estradiol which is a body-identical, bio-identical hormone akin to estrogen. Estrogen is a female sex hormone that plays a crucial role in regulating various processes in the body.

    Premarin vaginal cream is commonly used as a part of menopausal hormone therapy It is used to treat symptoms of menopause such as vaginal dryness, itching, and burning. 

    By replenishing the estrogen levels in the body, Premarin effectively addresses the discomfort and challenges that menopause brings. It helps restore hormonal balance and provides relief from the associated symptoms, improving overall well-being. It is available in different forms: tablet, cream and vaginal ring.

    Frequently Asked Questions

    The duration of use for Premarin cream can vary depending on the person and the specific condition being treated. It is best to consult with a healthcare provider for personalized advice on how long to use Premarin cream.



    Premarin cream is typically applied directly to the vaginal area. The best place to apply it is usually inside the vagina, using the applicator provided with the cream. However, it is important to follow the instructions provided by the healthcare provider or the product’s packaging.



    Vagifem is not the same as Premarin cream. Vagifem is a different brand name for a medication called estradiol vaginal tablets. Both medications are used to treat symptoms of vaginal atrophy and menopause, but they contain different types of estrogen hormones. It is important to consult with a healthcare provider to determine which medication is most suitable for an individual’s specific needs. 



    It’s advisable to avoid engaging in vaginal intercourse immediately after applying Premarin (conjugated estrogens). This is because the male partners may potentially absorb the estrogen through their skin, while females using Premarin (conjugated estrogens) may not absorb an adequate amount of the medication for it to be effective. Therefore, it is recommended to wait for a certain period of time after application before engaging in sexual activity. If you have any questions regarding the appropriate timing for using Premarin (conjugated estrogens), please consult your healthcare provider.



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