Safyral Birth Control Pills

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$126 generic equivalent, $0 with most insurance

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What is Safyral Birth Control Pills?

Safyral is a combination oral contraceptive pill (OCP, birth control medication, birth control pills) that prevents pregnancy by preventing the release of an egg (ovulation), and thickening the cervical mucus, blocking sperm from getting into the uterus and getting to the egg. Safyral is also prescribed to: treat acne, reduce the risk of ovarian cysts (as in polycystic ovarian syndrome [PCOS]), treat painful or heavy periods, and more. Read More

How to Use Safyral

Safyral is super easy to use.

Simply take one pill every day, at the same time each day. Many women find that taking Safyral before bedtime or just after their evening meal reduces nausea and other side effects.

After taking 21 days of active pills, you’ll switch to seven sugar pills (placebo pills). These are inactive pills with no hormones that are there to keep you in the habit of taking your pill every day and, in this medication, have Levomefolate (a vitamin B).

Safyral Dosage

Safyral uses a combination of two hormones estrogen (Ethinyl Estradiol, 30 mcg) and progestin (Drospirenone 3mg) to make your body think it’s pregnant so a real pregnancy won’t happen. It also has levomefolate, a B vitamin (451 mcg) on the last 7 tablets of the pack aka placebo days.

Benefits of Safyral

  • Periods get lighter. If you are usually a 7-day person, it goes down to like 5 days. If you use 5 pads/tampons a day, it goes down to 3.
  • You can use it to make #PeriodsOptional. Just skip the last week of pills and go straight into the next pack. See our CEO/Founder’s talk at the bottom of this page
  • Reduce the risk of ovarian cysts (as in polycystic ovarian syndrome [PCOS])
  • Improves acne.

Safyral Side Effects

The risks are very low, but some women have experienced unwanted side effects when taking Safyral.

Minor ones include breast tenderness, headaches, nausea, swollen feet or ankles, and slightly elevated blood pressure or blood sugar levels. Positive side effects are also a possibility, too — reduced acne, fewer mood swings, and other perks are fairly common.

The chances of serious side effects are extremely unlikely, but some cases have been documented. Symptoms include heart disease, blood clotting, shortness of breath, migraines, vision problems, slurred speech, confusion, and fainting. Those who wear contacts or are nearsighted may notice vision problems as well.

These may sound scary, but remember — they’re very rare.

Why Pandia Health?

FREE with insurance, $217/Pack without

FREE with insurance, $217/Pack without

FREE Delivery & Goodies

FREE Delivery & Goodies

Online prescription (skip the Dr. office visit and pharmacy lines)

Online prescription (skip the Dr. office visit and pharmacy lines)

Frequently Asked Questions


There is no direct link between Safyral and weight gain. Some women experience changes in their appetite that may lead to weight gain while taking Safyral. Others may find that their bodies retain more fluid while taking Safyral, even though they actually don’t gain any body fat.



One of our Patient Care Advisors or licensed physicians will always review the medications and supplements you’re currently taking before prescribing Safyral. Certain drugs (recreational, over-the-counter, or prescription) can interact with Safyral and make it less effective at preventing pregnancy. Drugs that may interact with Safyral include HIV drugs, anti-seizure drugs, antibiotics, and even herbal supplements like St. John’s wort.

Women who have high blood pressure or take medications to control blood pressure should not take Safyral. Our Pandia Health medical team recommends other options including progestin-only pill (POPs), IUDs with hormone (Mirena, Liletta, Kyleena, Skyla), copper IUDs, implants (nexplanon), the birth control shot (depo-provera), or condoms and spermicide.


If you choose to pay out-of-pocket, Safyral is an expensive birth control pill since it is a brand name, being $298 per pack. 


You shouldn’t smoke anyway, but especially not if you take estrogen containing birth control pills like Safyral. Smoking increases the risk of serious side effects like blood clots, especially in women who are older than 35.

Don’t take Safyral if you’re allergic to any of its ingredients. Signs and symptoms of an allergic reaction to Safyral are rare and usually very mild and may include itching, hives, or dizziness. Serious allergic reactions to Safyral can occur in very rare cases. Stop taking Safyral and call 911 immediately if you experience swelling in the lips, mouth, or tongue, or if you have a hard time breathing.

Safyral isn’t for everyone. Women with a history of certain medical conditions like heart disease, high blood pressure, kidney disease, liver cancer, or severe migraines should not take Safyral. Our Pandia Health Care Advisors are standing by to help you figure out the best birth control method given your health history.



It’s easy to get Safyral at just about any pharmacy near you with a doctor’s prescription. Concerned about your privacy? Our doctor-founded, doctor-led team at Pandia Health is happy to help you get Safyral or any other birth control you need, discreetly and conveniently.

If you don’t have insurance, don’t worry! Pandia Health has a range of payment options.


It’s not true that Safyral causes infertility. If you’re taking Safyral and want to have a baby, talk to your doctor and then stop taking the medication. Normal fertility should return within one or two menstrual cycles after your last pill. Dr. Yen explains more about birth control and infertility in this video. Watch to learn more!

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